New PDF release: Antifolate Drugs in Cancer Therapy

By Robert C. Jackson (auth.), Ann L. Jackman (eds.)

ISBN-10: 0896034607

ISBN-13: 9780896034600

ISBN-10: 1475745214

ISBN-13: 9781475745214

ISBN-10: 1592597254

ISBN-13: 9781592597253

In Antifolate medicines in melanoma treatment, Ann Jackman and a panel of very hot researchers comprehensively overview the present prestige of novel antifolates, a big type of anticancer medicinal drugs. the prestigious participants speak about the preclinical and scientific pharmacology of methotrexate, different dihydrofolate reductase inhibitors,
5-fluorouracil, and the hot new release of antifolates-the thymidylate synthase and glycinamide ribonucleotide formyltransferase inhibitors. additionally, they evaluate extensive the modulation of antifolate medicinal drugs, folate and antifolate delivery mechanisms, polyglutamation, resistance, and drug combos, in addition to pharmacogenomics, pharmacodynamics, rules of gene expression, and mechanisms of mobile loss of life.

The huge and innovative scope of Antifolate medicines in melanoma treatment offers entré to fascinating new avenues for destiny learn, and constitutes a brand new commonplace reference for all uncomplicated scientists and clinicians engaged in melanoma therapeutics.

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Extra info for Antifolate Drugs in Cancer Therapy

Example text

Sanghani S, Moran RG. Tight binding of folate substrates and inhibitors to recombinant mouse glycinamide ribonueleotide formyltransferase. Biochernistry 1997;36:10506-10516. 99. Pouliot JM, Beardsley GP, Almassey RJ. The polyglutamate binding region of human glycinamide ribonueleotide formyltransferase (hGARFT) spans the putative active site eleft. Pteridines 1997;8:129. 100. Rayl EA, Moroson BA, Beardsley GP. The human purH gene product, 5-aminoimidazole-4-carboxamide ribonueleotide formyltransferaselIMP cyelohydrolase.

Cloning ofhuman eDNAs eneoding mitoehondrial and eystosolic serine hydroxymethyltransferases and ehromosomalloealization. J Biol Chern 1993;268:11,910-11,916. 42. Stover PJ, Chen LH, Suh JR, Stover DM, Keyomarsi K, Shane B. Moleeular cloning, eharaeterization, and regulation of the human mitoehondrial serine hydroxymethyltransferase gene. J Biol Chern 1997;272:1842-1848. 43. Matthews RG, Ross J, Baugh CM, Cook JD and Davis L. Interactions of pig liver serine hydroxymethyltransferase with methyltetrahydropteroylpolyglutamate inhibitors and with tetrahydropteroylpolyglutamate substrates.

Effects of novel spermine analogues on cell cycle suppression and apoptosis in MALME3M human melanoma cells. Cancer Res 1997;57:5521-5527. 35. Houghton JA, Harwood FG, Tillman DM. Thymineless death in colon earcinoma eells is mediated via Fas signalling. Proc Natl Acad Sei USA 1997;94:8144-8149. 36. O'Dwyer PJ, King SA, Hoth DF, Leyland-Jones B. Role of thymidine in biochemieal modulation. Cancer Res 1987;47:3911-3919. 37. Sehireh V. Folates in serine and glyeine metabolism. In Folates and Pterins, vol.

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Antifolate Drugs in Cancer Therapy by Robert C. Jackson (auth.), Ann L. Jackman (eds.)

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