Download e-book for iPad: Amine Oxidases and Their Impact on Neurobiology: Proceedings by Prof. Dr. U. Trendelenburg (auth.), Prof. Dr. Peter

By Prof. Dr. U. Trendelenburg (auth.), Prof. Dr. Peter Riederer, Prof. Dr. Moussa B. H. Youdim (eds.)

ISBN-10: 3211822399

ISBN-13: 9783211822395

ISBN-10: 3709191130

ISBN-13: 9783709191132

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Extra resources for Amine Oxidases and Their Impact on Neurobiology: Proceedings of the 4th International Amine Oxidases Workshop, Wurzburg, Federal Republic of Germany, July 7–10, 1990

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In the last years, the 5-HT system was intensively investigated and nowadays, on the basis of radioligand assays, six different 5-HT receptors are to be distinguished (review Peroutka, 1987). g. , 1988). , 1987). A number of physiological functional correlates of these 5-HT receptors have been proposed (review Peroutka, 1987). Some of these physiological functions are considered to be characteristic for antidepressants. Many of the antidepressant treatments potentiate 5-HT functions and these effects persist during chronic treatment.

Both systems are modulated by antidepressant drugs including lithium and carbamazepine. These second messengers, in turn, modulate the phosphorylation status of neuronal proteins via protein kinase, which may lead to elevations of the above mentioned receptors and again their transduction systems. Introduction The discovery of the antidepressant activity of imipramine (Kuhn, 1957) and of the monoamine oxidase (MAO) inhibitor iproniazide (Crane, 1957) enormously stimulated biological investigations on the pathophysiology of 30 M.

Our finding that the placenta had approximately equal concentrations of both 44 J. C. Shih et al. 0:: Q) E U- :::> ~ t- ~ >- Q) C. -0 Q 2 .... /) -... 0 'cQ) c u 0 '0.. /) CL u... c (J MAO A a. I (J ra J: ~ -5kb -2 kb MAO 8 rONA b -3kb -4 Kb Fig. 1. MAO-A and B mRNA distribution in (a) various tissues and (b) brain regions. lg RNA from various 19-week fetal tissues were loaded in each lane, electrophoresed and blotted onto a nylon membrane. The same blot was hybridized in sequence with 32P-labeled probes for MAO-A (As, A9 , A IO ): MAO-B (Bl' B2 , B 3 ); and 28s rDNA.

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Amine Oxidases and Their Impact on Neurobiology: Proceedings of the 4th International Amine Oxidases Workshop, Wurzburg, Federal Republic of Germany, July 7–10, 1990 by Prof. Dr. U. Trendelenburg (auth.), Prof. Dr. Peter Riederer, Prof. Dr. Moussa B. H. Youdim (eds.)


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