Download PDF by Gabriella Castoria, Antimo Migliaccio: Advances in Rapid Sex-Steroid Action: New Challenges and New

By Gabriella Castoria, Antimo Migliaccio

ISBN-10: 1461417635

ISBN-13: 9781461417637

ISBN-10: 1461417643

ISBN-13: 9781461417644

Breast and prostate cancers are either hormone-dependent, a minimum of in a few phases in their development. Hormonal manipulation represents a big healing strategy. even if such a lot of breast and prostate cancers at the beginning reply to hormone treatment, such a lot tumors reinitiate to development. ultimately, hormone-resistant and metastatic breast and prostate cancers may possibly strengthen. therefore, the problem is the dissection of mechanisms through which steroid receptor signaling pathways proceed to persuade cellphone progress and invasiveness. Compelling facts shows that steroid hormones elicit non-genomic responses in extra-nuclear compartment of aim cells. during this mobile place, steroid-coupled receptors speedily recruit signaling effectors or scaffold proteins and turn on a number of pathways resulting in proliferation, survival, migration and invasiveness. The instant problem is the dissection of key occasions regulating the steroid reaction of objective tissues to avoid development and increase remedy of breast and prostate cancers.

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Extra info for Advances in Rapid Sex-Steroid Action: New Challenges and New Chances in Breast and Prostate Cancers

Sample text

De Donatis A, Comito G, Buricchi F, Vinci MC, Parenti A, Caselli A, Camici G, Manao G, Ramponi G, Cirri P (2008) Proliferation versus migration in platelet-derived growth factor signaling: the key role of endocytosis. J Biol Chem 283:19948–19956 14. Castoria G, Lombardi M, Barone MV, Bilancio A, Di Domenico M, Bottero D, Vitale F, Migliaccio A, Auricchio F (2003) Androgen stimulated DNA synthesis and cytoskeletal changes in fibroblasts by a non transcriptional receptor action. J Cell Biol 161:547–556 15.

J. Parsons et al. e. ER or PR) heregulin insulin-like growth factor-1 ligand-binding domain modulator of non-genomic action of estrogen receptor Matrix metallo-proteinase non-small cell lung cancer PI3-kinase progesterone receptor serine Src family kinase Src homology 3 steroid coactivator-1 transforming growth factor tyrosine kinase inhibitor tyrosine Contents 1 2 3 Introduction..........................................................................................................................

Parsons et al. e. ER or PR) heregulin insulin-like growth factor-1 ligand-binding domain modulator of non-genomic action of estrogen receptor Matrix metallo-proteinase non-small cell lung cancer PI3-kinase progesterone receptor serine Src family kinase Src homology 3 steroid coactivator-1 transforming growth factor tyrosine kinase inhibitor tyrosine Contents 1 2 3 Introduction..........................................................................................................................

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Advances in Rapid Sex-Steroid Action: New Challenges and New Chances in Breast and Prostate Cancers by Gabriella Castoria, Antimo Migliaccio


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