George F. Vande Woude (ed.), George Klein (ed.)'s Advances in Cancer Research, Vol. 108 PDF

By George F. Vande Woude (ed.), George Klein (ed.)

ISBN-10: 012380888X

ISBN-13: 9780123808882

Offers beneficial info at the fascinating and fast-moving box of melanoma research. Outstanding and unique stories are provided on numerous issues.

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Extra resources for Advances in Cancer Research, Vol. 108

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However, it is still unclear whether a specific combination of these factors is associated with the risk of the development of HCC. In one of our prospective studies, the risk of HCC was shown to increase approximately fivefold among men infected with HBV genotype C compared with genotype B. , 2005). These observations suggest additive risks of viral load and HBV genotype C in the development of HCC. , 2008). We recently investigated the independent and interactive effects of each known viral factor on the development of HCC.

2008). , 2007). Therefore, irrespective of the etiology, chronic inflammation of the liver is recognized as the critical predisposing factor in most HCCs. The mediators of liver inflammation are mainly immune-related cells and the inflammatory factors they produce, which are abnormally enriched in the local inflammatory microenvironment. Viral infection can recruit macrophages (Kupffer cells), T cells, and other immune cells to the microenvironment, which have been reported to orchestrate the microenvironment for tumor initiation or progression.

Overall, at least 75–80% of HCC are attributable to persistent viral infections with either HBV (50–55%) or HCV (25–30%). , 2008; Kao and Chen, 2005; Lok, 2004). In HBV endemic countries, chronic HBV infection has the strongest association with the development of HCC (Kao and Chen, 2002; Lok, 2004). Several lines of evidence have strongly indicated an etiologic association between persistent HBV infection and HCC, including the geographical correlation between prevalence of chronic HBV infection and incidence of HCC (Fig.

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Advances in Cancer Research, Vol. 108 by George F. Vande Woude (ed.), George Klein (ed.)

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